Mucoadhesive drug delivery system is a part of controlled delivery system. The specific aim of this work was to prepare mucoadhesive patches containing tetracycline hydrochloride and carvacrol in an attempt to develop a novel oral drug delivery system for the treatment of mouth infections. Formulation and invitro evaluation of mucoadhesive buccal. The polymers were dissolved in casting solvent 10 ml and plasticizer 30% were incorporated then calculated amount of drug dissolved in methanol 2. Formulation and evaluation of buccal patches for delivery. Preparation and evaluation of buccal patches of clotrimazole for oral candida infections. The use of mucoadhesive polymers in buccal drug delivery has gained a great attention. Literature studies on preparation and evaluation of buccal. Mucoadhesive buccal patches formulations reported in the literature. Various mucoadhesive dosage forms, including tablets, patches, disks, wafers, ointments and gels have recently been developed. Preparation of patches buccal mucoadhesive patches were prepared using polymer or polymers blends along with the drug and a suitable solvent.
Formulation, development and invitro evaluation of. Development of mucoadhesive buccal patches for controlled delivery of anti diabetic drug 11 animal ethics committee1009. Buccal patches films they are long, flat, thin thickness, transparent with high surface area. Mucoadhesive buccal patches and use of natural polymer in its. The buccal mucoadhesive films of resperidone were prepared using hpmc 47cps and hpmc 15 cps polymers by casting method. And then this route is well mucoadhesive polymers are pivotal in the development of vascularized with venous blood draining the buccal buccal delivery systems which enable retention at the mucosa reaching the heart directly via the internal jugular buccal mucosal surface so providing intimate contact vein. Oral patches are usually laminates consisting of an impermeable backing layer and a. The solution was prepared by adding pcl to a blend of dcm and dmf.
For patient compliance the patches were adhered to mucous membrane of buccal cavity two times a day and the therapeutic efficacy will be maintained for 24 h. The three major factors in determining the requisite formulation of buccal films are mucoadhesive properties, permeation enhancement, and controlled release. Ch and carvedilol were dissolved in 2% vv glacial acetic acid solution containing ammonium acetate 5 m and pe was dissolved in distilled water. He used hpmc e 15 as main polymer for preparation of buccal patch using solvent casting method. Preparation of mucoadhesive oral patches containing.
Buccal patches are highly flexible and thus much more readily tolerated by the patient than tablets. Mucoadhesive buccal patches of ss which bypass the hepatic metabolism and release the drug at a desired. Chitosan based mucoadhesive buccal patches containing. Preparation of mucoadhesive patches for buccal administration of metoprolol succinate. The patches were prepared by the solvent casting method. The desired percentage of chitosan was chitosan based mucoadhesive buccal patches containing bisoprolol fumarate sarath chandran c, kv. From the present study carried out on simvastatin buccal patches prepared from 1%.
Preparation and evaluation of mucoadhesive buccal films of clotrimazole for oral candida infections. However, buccal patch offer greater flexibility and comfort than the other devices. The use of mucoadhesive polymers in buccal drug delivery has a greater application. Aug 06, 2012 formulation and evaluation of mucoadhesive buccal patches of labetalol. Mucoadhesive buccal tablets are prepared by compression of mono or multi. Formulation and evaluation of buccal patches of simvastatin. Permeation of ond was calculated ex vivo using porcine buccal membrane. Buccal mucoadhesive tablets are dry placing in contact with buccal mucosa. Mucoadhesive preparations contain one or more active substances intended for systemic absorption through the buccal mucosa over a prolonged period of time. They may be supplied as mucoadhesive buccal tablets or as other mucoadhesive solid or semisolid preparations.
For mucoadhesive measurements, films were cut in portions of 4 cm 2 and pasted on a support, connected to the dynamometer lehrmittelban, professor dr. Development of mucoadhesive patches for buccal administration. Formulation and evaluation of mucoadhesive buccal films of. Mucoadhesive buccal patches were prepared using different grades of hydroxypropyl methylcellulose hpmc k4m and k100m and. Development of mucoadhesive patches for buccal administration of prochlorperazine.
Preparation of buccal mucoadhesive controlled drug delivery systems of lercanidipine hydrochloride using various mucoadhesive and rate controlling polymers either alone or in combination. Various mucoadhesive devices, including tablets, films, patches, disks, strips, ointments and gels, have recently been developed. Formulation and evaluation of buccal patches for delivery of. Buccal patches for the delivery of atenolol using sodium alginate with various hydrophilic polymers like carbopol 934 p, sodium carboxymethyl cellulose, and hydroxypropyl methylcellulose in various proportions and combinations were fabricated by solvent casting technique. Evaluation of zolmitriptan mucoadhesive buccal patches. Buccal mucoadhesive tablets 12 buccal mucoadhesive patchesgels buccal mucoadhesive tablets of lercanidipine. Chitosan, a derivative form of chitin, is a naturally. Mucoadhesive bilayered patches for administration of.
The purpose of this study was to develop and optimize formulations of mucoadhesive bilayered buccal patches of sumatriptan succinate using chitosan as the base matrix. The reported mucoadhesive buccal patches drug delivery system are summarized here. Development of mucoadhesive patches for buccal administration of carvedilol. Apr 10, 20 administering the drug via membrane located below the tongue is called sublingual ddssldds generally called floor of mouth. The sldds is almost similar to the bdds having some more advantages than buccal drug delivery system. Mucoadhesive buccal films were prepared by solvent casting. In the present investigation, buccal films were prepared with 2 mg glimepiride twice a day to develop a sustain release formulation for treatment of type 2 diabetes. Preparation of bisoprolol fumarate buccal patches3 the buccal patches containing bpl were prepared by solvent casting method with required modification table no. Formulation and evaluation of buccal patches of simvastatin by. Preclinical evaluation of novel mucoadhesive bilayer patches for. The prepared buccal patches were evaluated for following properties like weight uniformity, thickness, folding endurance, surface ph, swelling index, invitro residence time, tensile strength, drug content, invitro release study, stability study.
Formulation and evaluation of rabeprazole buccal patches. Preparation of mucoadhesive buccal patches the buccal patches were prepared by solvent casting technique. The objective of this study was to develop mucoadhesive buccal tablets of simvastatin using. Various natural polymers which can be used in mucoadhesive buccal patches are chitosan, sodium alginate, tragacanth, gelatin and guar gum etc. Mucoadhesive patch were weighed individually x 0 and placed separately in 2% agar gel plates and incubated at 370c10c. Formulation and optimization of mucoadhesive buccal patches of.
In this study mucoadhesive buccal patches were prepared. Formulation and evaluation of mucoadhesive buccal patches. Evaluation of in vitro release and mechanical properties chandra sekhar kollia, ramesh gannub, vamshi vishnu yamsanib, kishan vb and madhsudan rao yamsanib acollege of pharmacy and health sciences, mercer university, atlanta, georgia, usa30341. The bilayered patches were prepared using ethyl cellulose as a backing layer and carbopol 934 as a matrix mucoadhesive layer. Mucoadhesive buccal patch releasing drug in the oral cavity at a predetermined rate may present distinct advantages over traditional dosage forms, such as tablets, gels and solutions. Formulation and evaluation of mucoadhesive buccal films of enalapril maleate a. Evaluation of mucoadhesive buccal patches can perform as mention below. Mucoadhesive buccal patches based on interpolymer complexes. The oral route is the most popular and convenient route of drug administration available. Formulation and evaluation of mucoadhesive buccal patches of. Though there is ample of work done in this field of mucoadhesive patch development but clinical usage is flimsy. Garhwal university, srinagar garhwal246 174, india semalty, et al mucoadhesive buccal films of enalapril. Mucoadhesive buccal patches can be prepared by methods mentioned below. In the present study, the bioadhesive polymer chitosan was used for the preparation of buccal patches3,4.
The goal of the present investigation was to design and evaluate mucoadhesive buccal patches of pantoprazole which offers an attractive route of administration for systemic drug delivery. The buccal patches were prepared by solvent casting method using chitosan. Sathish and shayeda abstract patches of cyproheptadine hydrochloride cph which is a sedating antihistamine with antimuscarinic, serotoninantagonist, and calciumchannel blocking action. Mucoadhesion involves several types of bonding mechanisms, and it is the interaction between each process that allows for the adhesive process. The major categories are wetting theory, adsorption theory, diffusion theory, electrostaticic theory, and fracture theory. Generally factors affecting the sldds are almost similar to factors related with the bdds.
In vitro and in vivo drug release and bioadhesion navneet verma 1,2 and pronobesh chattopadhyay 3 1college of pharmacy, iftm university, moradabad244001 u. The ipc was prepared using chitosan and carboxymethylated feronia limonia fruit pulp mucilage. Buccal tablets of prochlorperazine maleate 6 brief resume of the intended work 6. Formulation and evaluation of buccal patches for delivery of atenolol. Moreover, buccal patches provide more flexibility than other drug deliveries.
Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon 889 swelling index the swelling index was measured using the diameter method. Formulation and evaluation of mucoadhesive buccal patch of. Development of mucoadhesive patches for buccal administration of ibuprofen article in journal of controlled release 991. Effect of permeation enhancers in the mucoadhesive buccal. Ann rose augusthy 1, vipin k v 2, sarath chandran c 2, muhammed nizar av 2, and sreeraj k 3. Formulation and evaluation of metformin hydrochloride buccal. A piece of porcine buccal mucosa was glued on a support and kept in a vessel placed in a thermostatic bath at 37 c 0.
Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride. Preparation of mucoadhesive buccal patches buccoadhesive patches were prepared by solvent casting method. Mucoadhesive buccal patches of lisinopril were prepared by using solvent. Jun 09, 2010 the buccal cavity is easily accessible for self medication, and hence it is safe and well accepted by patients, since buccal patches can be very easily administered and even removed from the application site, terminating the input of drug whenever desired. An approach to prepare buccal patches using chitosan and hpmc polymers jose, jobin, charyulu, r. Formulation and preparation of mucoadhesive buccal patches of. New insight into the fabrication of smart mucoadhesive. They can be prepared by two methods solvent casting method direct milling method 32020 31 department of pharmaceutical technology, lj institute of pharmacy, ahmedabad. Preparation of mucoadhesive patches for buccal administration. Amongst them, buccal patches offer greater flexibility and comfort than the other forms. Manufacture and characterization of mucoadhesive buccal films. Patches also ensure more accurate dosing of the drug compared to gel and ointment. A buccal patch for systemic administration of acyclovir in the oral cavity was developed using polymers hydroxy.
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